According to Bloomberg Business Week, it's Eddie Murphy. His 38 movies have grossed $5.79 billion dollars. Rounding out the top 5 are Dan Ackroyd, Robert Downey Jr, Ben Stiller and Bill Murray.
The female with the highest score and this is not really a surprise as she has had support roles in tons of successful movies: Joan Cusack at #10 with $2.81 billion.
It does seem like their is a Saturday Night Live alum in almost anything you watch these days. What a training ground.